Effect of nonsurgical periodontal therapy on interleukin-34 levels in periodontal health and disease
| Autor: | C N Guruprasad, A R Pradeep |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Indian Journal of Dental Research, Vol 29, Iss 3, Pp 280-285 (2018) |
| Druh dokumentu: | article |
| ISSN: | 0970-9290 1998-3603 |
| DOI: | 10.4103/ijdr.IJDR_527_17 |
| Popis: | Background: Interleukin-34 (IL-34) is a recently identified alternative ligand for colony-stimulating factor-1 receptor plays an important role in osteoclastogenesis. The aim of this study was to evaluate the IL-34 levels in gingival crevicular fluid (GCF) and plasma in subjects with chronic periodontitis and to evaluate the effect of nonsurgical periodontal therapy on the GCF and plasma IL-34 levels. Materials and Methods: Thirty individuals (age range: 30–56 years) were selected and divided into groups based on the gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss): Group I (15 individuals with healthy periodontium), Group II (15 individuals with chronic generalized periodontitis) while Group II patients after 8 weeks of the treatment (scaling and root planning) constituted Group III. GCF samples and plasma samples were collected to estimate the levels of IL-34 using enzyme-linked immunosorbent assay kit. Results: The mean IL-34 concentration in GCF and plasma was highest for Group II compared to Group I and decreased after nonsurgical periodontal therapy in chronic generalized periodontitis group. The difference between them was statistically significant (P < 0.05). Conclusion: IL-34 can be considered as an “inflammatory marker” of periodontal disease and can be explored in the future as a potential therapeutic target in the treatment of periodontal disease. |
| Databáze: | Directory of Open Access Journals |
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