Value of original and modified pathological scoring systems for prognostic prediction in paraffin-embedded donor kidney core biopsy

Autor:	Jinghong Tan, Huanxi Zhang, Longshan Liu, Jun Li, Qian Fu, Yan Li, Chenglin Wu, Ronghai Deng, Jiali Wang, Bowen Xu, Wenfang Chen, Shicong Yang, Changxi Wang
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	Kidney transplantation pretransplant donor kidney biopsy core biopsy pathology glomerulosclerosis eGFR Diseases of the genitourinary system. Urology RC870-923
Zdroj:	Renal Failure, Vol 46, Iss 1 (2024)
Druh dokumentu:	article
ISSN:	0886022X 1525-6049 0886-022X
DOI:	10.1080/0886022X.2024.2314630
Popis:	Background No study has validated, compared and adapted scoring systems for prognosis prediction based on donor kidney core biopsy (CB), with less glomeruli than wedge biopsy.Methods A total of 185 donor kidney CB specimens were reviewed using seven scoring systems. The association between the total score, item scores, score-based grading, and allograft prognosis was investigated. In specimens with less than ten glomeruli (88/185, 47.6%), scoring systems were modified by adjusting weights of the item scores.Results The Maryland aggregate pathology index (MAPI) score-based grading and periglomerular fibrosis (PGF) associated with delayed graft function (DGF) (Grade: OR = 1.59, p
Databáze:	Directory of Open Access Journals
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