Mus81-Mms4 endonuclease is an Esc2-STUbL-Cullin8 mitotic substrate impacting on genome integrity
| Autor: | Anja Waizenegger, Madhusoodanan Urulangodi, Carl P. Lehmann, Teresa Anne Clarisse Reyes, Irene Saugar, José Antonio Tercero, Barnabas Szakal, Dana Branzei |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2041-1723 98466291 |
| DOI: | 10.1038/s41467-020-19503-4 |
| Popis: | Mus81-Mms4 endonuclease is critical for processing various DNA recombination structures. Here the authors uncover a regulatory mechanism of the endonuclease via posttranslational modifications involving SUMOylation and ubiquitylation that impact on genome integrity. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|