An Investigation of ABO Blood Type and the Platelet Delta Granule Storage Pool
| Autor: | Ryan J. Reagans, Paula M. Kramer, Jacob A. Cichocki, William T. Gunning |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis, Vol 27 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1938-2723 10760296 30064848 |
| DOI: | 10.1177/10760296211068818 |
| Popis: | Individuals with bleeding tendencies are more likely to have blood type O than blood types A, B, or AB. Platelet storage pool deficiencies are a lesser-known group of bleeding disorders which often go undiagnosed and may account for a significant number of patients with unexplained bleeding defects. We hypothesized that patients with platelet δ-storage pool deficiency might also have a predominance of type O blood. A retrospective review of medical records of 2,020 patients with unexplained bleeding and evaluated for δ-storage pool deficiency was performed. Correlations between dense granule numbers, blood type, and von Willebrand factor were analyzed for statistical differences. 51.5% of blood samples were blood type O compared to an incidence of 44.0% in the U.S. population. There was a significant association of vWF and blood type O but not with the delta storage pool. There is a preponderance of blood type O in the study population compared to the U.S. population. There is no statistically significant link between blood type O and lower dense granule numbers in this study. |
| Databáze: | Directory of Open Access Journals |
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