Use of intravoxel incoherent motion imaging to monitor a rat kidney chronic allograft damage model

Autor: Qiang Zhang, Zexing Yu, Song Zeng, Lu Liang, Yue Xu, Zijian Zhang, Hao Tang, Wenjiao Jiao, Wenrui Xue, Wei Wang, Xiaodong Zhang, Tao Jiang, Xiaopeng Hu
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: BMC Nephrology, Vol 20, Iss 1, Pp 1-10 (2019)
Druh dokumentu: article
ISSN: 1471-2369
DOI: 10.1186/s12882-019-1545-1
Popis: Abstract Background Chronic allograft damage (CAD) is the leading cause of long-term graft dysfunction. A noninvasive method that can diagnose CAD early and monitor its development is needed. Methods Kidneys from Fisher rats were transplanted into Lewis rats to establish a CAD model (n = 20). The control group underwent syngeneic kidney transplantation (n = 20). The serum creatinine of the rats was monitored. At 4, 12, and 20 weeks after modeling, a magnetic resonance imaging (MRI) examination was performed. The apparent diffusion coefficient (ADC), pseudo diffusion coefficient (D*), true diffusion coefficient (D) and perfusion fraction (f) of the two groups were analyzed. Chronic allograft damage index (CADI) scoring was used to evaluate the transplanted kidney specimens. Immunohistochemistry was used to detect the expression of fibrosis markers in the transplanted kidney tissues and to analyze their correlations with all MRI parameters. Results The transplanted kidneys in the experimental group developed CAD changes before the appearance of elevated creatinine. The MRI parameters in the experimental group [ADC (1.460 ± 0.109 VS 2.095 ± 0.319, P
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