| Autor: |
Magdy Mohammed Mahdy, Mostafa Samy Abbas, Emad Zarief Kamel, Mohamed Fathy Mostafa, Ragaa Herdan, Shimaa Abbas Hassan, Ramy Hassan, Ahmed M. Taha, Tameem M. Ibraheem, Bashir A. Fadel, Mohammed Geddawy, Jehan Ahmed Sayed, Osama Ali Ibraheim |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
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| Zdroj: |
BMC Anesthesiology, Vol 19, Iss 1, Pp 1-9 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2253 |
| DOI: |
10.1186/s12871-019-0779-6 |
| Popis: |
Abstract Background Terlipressin, in general, is a vasopressor which acts via V1 receptors. Its infusion elevates mean blood pressure and can reduce bleeding which has a splanchnic origin. The primary outcome was to assess the impact of intraoperative terlipressin infusion on portal venous pressure during hepatobiliary surgery; the 2ry outcomes included effects upon systemic hemodynamics, estimated blood loss, and postoperative renal functions. Methods This prospective randomized study involved 50 patients undergoing hepatobiliary surgery who were randomly and equally allocated into terlipressin group, or a control group. The terlipressin group received an initial bolus dose of (1 mg over 30 min) followed by a continuous infusion of 2 μg/kg/h throughout the procedure and gradually weaned over the first four postoperative hours, whereas the control group received the same volumes of normal saline. The portal venous pressure changes were measured directly through a portal vein angiocatheter. Results Portal pressure was significantly reduced over time in the terlipressin group only (from 17.88 ± 7.32 to 15.96 ± 6.55 mmHg, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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