Which papillary thyroid microcarcinoma should be treated as 'true cancer' and which as 'precancer'?

Autor: Krzysztof Kaliszewski, Dorota Diakowska, Beata Wojtczak, Zdzisław Forkasiewicz, Dominika Pupka, Łukasz Nowak, Jerzy Rudnicki
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: World Journal of Surgical Oncology, Vol 17, Iss 1, Pp 1-8 (2019)
Druh dokumentu: article
ISSN: 1477-7819
DOI: 10.1186/s12957-019-1638-0
Popis: Abstract Background Papillary thyroid microcarcinoma (PTMC) generally is a cancer with excellent prognosis, but the term “cancer” sounds severe and harsh, which can elicit emotional and physical responses from patients. To eliminate the word “cancer,” the term noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) was introduced. However, not all PTMCs can be classified as NIFTP. Sometimes, very aggressive PTMC cases might be observed. Some authors suggest that one of the risk factors for poor prognosis is lymph node metastasis. The aim of the study was to evaluate some clinicopathological features of PTMC as the risk factors for lymph node metastasis. Material and methods We performed a retrospective chart review and selected 177 patients with PTMC. To analyze the cases with potentially aggressive behavior, we enrolled PTMC patients with lymph node metastases (pN1, central, and/or lateral) and evaluated some of their clinicopathological features. Results The logistic regression analysis results demonstrated significantly higher rates of multifocal or bilateral tumor occurrence in the PTMC patients with pN1 than in the patients with pN0 (P
Databáze: Directory of Open Access Journals
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