2045 The role of TGFβ in driving early cystic fibrosis lung disease

Autor: Elizabeth L. Kramer, William Hardie, Kristin Hudock, Cynthia Davidson, Alicia Ostmann, John P. Clancy
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Journal of Clinical and Translational Science, Vol 2, Pp 33-33 (2018)
Druh dokumentu: article
ISSN: 2059-8661
DOI: 10.1017/cts.2018.139
Popis: OBJECTIVES/SPECIFIC AIMS: Transforming growth factor-beta (TGFβ) is a genetic modifier of cystic fibrosis (CF) lung disease. TGFβ’s pulmonary levels in young CF patients and its mechanism of action in CF are unknown. We examined TGFβ levels in children with CF and investigated responses of human airway epithelial cells (AECs) and mice to TGFβ. METHODS/STUDY POPULATION: TGFβ levels in bronchoalveolar lavage fluid from CF patients (n=15) and non-CF control patients (n=21)
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