Evaluation of microvasculopathy using dual-energy computed tomography in patients with chronic thromboembolic pulmonary hypertension

Autor: Hiroyuki Onishi, Yu Taniguchi, Yoichiro Matsuoka, Kenichi Yanaka, Yu Izawa, Yasunori Tsuboi, Shumpei Mori, Atsushi Kono, Kazuhiko Nakayama, Noriaki Emoto, Ken-ichi Hirata
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Pulmonary Circulation, Vol 11 (2021)
Druh dokumentu: article
ISSN: 2045-8940
20458940
DOI: 10.1177/2045894020983162
Popis: The existence of microvasculopathy in patients with chronic thromboembolic pulmonary hypertension has been suggested. Recently, dual-energy computed tomography has been used to produce a sensitive iodine distribution map in lung fields to indicate microvasculopathy according to poor subpleural perfusion. Our aim was to evaluate the impact of microvasculopathy on pathophysiology in chronic thromboembolic pulmonary hypertension. According to the extent of poor subpleural perfusion, ninety-three interventional treatment-naïve patients were divided into poorly perfused ( n = 49) or normally perfused group ( n = 44). We assessed cardiopulmonary exercise test, right heart catheterization, and dual-energy computed tomography parameters for quantitative evaluation of lung perfusion of blood volume score. Lung perfusion of blood volume score in normally perfused group was significantly inversely correlated with pulmonary vascular resistance (pulmonary vascular resistance = 6816.1 × lung perfusion of blood volume score −0.793 , R 2 = 0.225, p
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