Potential use of corneal confocal microscopy in the diagnosis of Parkinson’s disease associated neuropathy

Autor:	Ning-Ning Che, Hong-Qi Yang
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Parkinson’s disease Peripheral neuropathy Corneal confocal microscopy Small fiber neuropathy Neurology. Diseases of the nervous system RC346-429
Zdroj:	Translational Neurodegeneration, Vol 9, Iss 1, Pp 1-10 (2020)
Druh dokumentu:	article
ISSN:	2047-9158
DOI:	10.1186/s40035-020-00204-3
Popis:	Abstract Parkinson’s disease (PD) is a chronic, progressive neurodegenerative disease affecting about 2–3% of population above the age of 65. In recent years, Parkinson’s research has mainly focused on motor and non-motor symptoms while there are limited studies on neurodegeneration which is associated with balance problems and increased incidence of falls. Corneal confocal microscopy (CCM) is a real-time, non-invasive, in vivo ophthalmic imaging technique for quantifying nerve damage in peripheral neuropathies and central neurodegenerative disorders. CCM has shown significantly lower corneal nerve fiber density (CNFD) in patients with PD compared to healthy controls. Reduced CNFD is associated with decreased intraepidermal nerve fiber density in PD. This review provides an overview of the ability of CCM to detect nerve damage associated with PD.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bcb8ac2fa6b9432bbca3d874b5cd5a9a Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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