Diagnostic role and prognostic impact of positron emission tomography/computed tomography in patients treated for uterine corpus cancer
Autor: | Stojiljković Milica, Šobić-Šaranović Dragana, Odalović Strahinja, Petrović Jelena, Popović-Krneta Marina, Veljković Miloš, Ranković Nevena, Artiko Vera |
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Jazyk: | English<br />Serbian |
Rok vydání: | 2024 |
Předmět: | |
Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 152, Iss 3-4, Pp 168-174 (2024) |
Druh dokumentu: | article |
ISSN: | 0370-8179 2406-0895 |
DOI: | 10.2298/SARH230504013S |
Popis: | Introduction/Objective. The goal of our research was to evaluate diagnostic and prognostic role of positron emission tomography/computed tomography (PET-CT) in patients previously treated for uterine cancer and compare it to conventional imaging methods (CIM). Methods. We analyzed 37 patients examined on PET-CT for follow-up or suspicion of uterine cancer recurrence, and who were previously treated with surgery and/or chemoradiotherapy. All patients underwent CT or magnetic resonance imaging prior to PET-CT, and were followed-up for at least one year. Results. PET-CT showed sensitivity, specificity and diagnostic accuracy in uterine cancer relapse detection of 96.3%, 70%, and 89.2%, while those values for CIM were 92.6%, 40%, and 78.4 %, respectively. Correlation of PET-CT and CIM findings was 78% (29/37). In 13 out of 25 true positive patients on CIM, PET-CT found greater number of active sites missed by conventional imaging. Positive findings on PET-CT were associated with shorter progression free survival (p = 0.023, logrank test). Conclusion. PET-CT constitutes an important diagnostic method in management of recurrent cancer of uterine corpus, demonstrating high sensitivity and accuracy. In comparison to CIM, PET-CT can discover larger number of active tumor sites, and also shows better specificity. PET-CT positive patients have worse prognosis with shorter progression free survival. |
Databáze: | Directory of Open Access Journals |
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