Antithrombotic and Flow Drag‐Reducing Material for Blood‐Contacting Medical Devices

Autor: Justin Kok Soon Tan, Elaine Shi An Chen, Yibing Dong, Hui Fang, Cho Yeow Koh, R. Manjunatha Kini, Sangho Kim, Hwa Liang Leo, Choon Hwai Yap
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Advanced Materials Interfaces, Vol 10, Iss 10, Pp n/a-n/a (2023)
Druh dokumentu: article
ISSN: 2196-7350
20220227
DOI: 10.1002/admi.202202270
Popis: Abstract Blood‐contacting medical devices are often associated with shear‐induced and contact activation thrombosis. Superhydrophobic materials have shown promise to reduce flow drag forces, but not contact activation. Here, a strategy of selectively grafting a potent anti‐thrombin compound on the tips of the surface microstructures of a superhydrophobic polytetrafluoroethylene foam, is presented, to concurrently achieve drag reduction and anti‐thrombosis. This work shows that two grafting approaches – Argon plasma or piranha solution treatment – followed by covalent cross‐linking can successfully graft the drug to the outer tips of the foam and provide anti‐thrombotic functionality. By avoiding grafting to the inner regions of the foam, the surface's drag reduction properties can be retained. The functional durability of the grafted surfaces is evaluated by strong water jetting, which demonstrates that the plasma approach can withstand substantial fluid shearing but not the piranha approach, although the plasma approach involves stronger compromise to the drag reduction capabilities. As the proposed selective grafting strategy is applied to a bulk foam, it can be complemented with a previously proposed strategy of supplying air pressure to the foam pores to bolster resistance to fluid impalement and plastron dissolution, allowing the material to be used in medical devices with high fluid pressures.
Databáze: Directory of Open Access Journals
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