| Autor: |
Mauro De Nisco, Antonio Di Maio, Michele Manfra, Carmine Ostacolo, Alessia Bertamino, Pietro Campiglia, Isabel M. Gomez-Monterrey, Silvana Pedatella |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Reactions, Vol 3, Iss 1, Pp 192-202 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2624-781X |
| DOI: |
10.3390/reactions3010014 |
| Popis: |
The selective N-4 alkylation of cytosine plays a critical role in the synthesis of biologically active molecules. This work focuses on the development of practical reaction conditions toward a regioselective synthesis of N-4-alkyl cytosine derivatives. The sequence includes a direct and selective sulfonylation at the N-1 site of the cytosine, followed by the alkylation of the amino site using KHMDS in CH2Cl2/THF mixture, providing a fast and efficient approach consistent with pyrimidine-based drug design. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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