The anticancer drug tamoxifen is active against Trypanosoma cruzi in vitro but ineffective in the treatment of the acute phase of Chagas disease in mice
| Autor: | Danilo Ciccone Miguel, Marcela Lencine Ferraz, Rosana de Oliveira Alves, Jenicer KU Yokoyama-Yasunaka, Ana Claudia Torrecilhas, Alvaro José Romanha, Silvia RB Uliana |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 105, Iss 7, Pp 945-948 (2010) |
| Druh dokumentu: | article |
| ISSN: | 0074-0276 1678-8060 |
| DOI: | 10.1590/S0074-02762010000700021 |
| Popis: | The activity of the antineoplastic drug tamoxifen was evaluated against Trypanosoma cruzi. In vitro activity was determined against epimastigote, trypomastigote and amastigote forms of CL14, Y and Y benznidazole resistant T. cruzi strains. Regardless of the strain used, the drug was active against all life-cycle stages of the parasite with a half maximal effective concentration ranging from 0.7-17.9 µM. Two experimental models of acute Chagas disease were used to evaluate the in vivo efficacy of treatment with tamoxifen. No differences in parasitemia and mortality were observed between control mock-treated and tamoxifen-treated mice. |
| Databáze: | Directory of Open Access Journals |
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