Role of LncRNA H19 in tumor progression and treatment

Autor: Linjing Li, Yuting Gao, Boyi Yu, Jiahao Zhang, Guorong Ma, Xiaodong Jin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Molecular and Cellular Probes, Vol 75, Iss , Pp 101961- (2024)
Druh dokumentu: article
ISSN: 0890-8508
33060525
DOI: 10.1016/j.mcp.2024.101961
Popis: As one of the earliest discovered lncRNA molecules, lncRNA H19 is usually expressed in large quantities during embryonic development and is involved in cell differentiation and tissue formation. In recent years, the role of lncRNA H19 in tumors has been gradually recognized. Increasing evidence suggests that its aberrant expression is closely related to cancer development. LncRNA H19 as an oncogene not only promotes the growth, proliferation, invasion and metastasis of many tumors, but also develops resistance to treatment, affecting patients' prognosis and survival. Therefore, in this review, we summarise the extensive research on the involvement of lncRNA H19 in tumor progression and discuss how lncRNA H19, as a key target gene, affects tumor sensitivity to radiotherapy, chemotherapy and immunotherapy by participating in multiple cellular processes and regulating multiple signaling pathways, which provides a promising prospect for further research into the treatment of cancer.
Databáze: Directory of Open Access Journals
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