MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer

Autor: Chiara Turco, Gabriella Esposito, Alessia Iaiza, Frauke Goeman, Anna Benedetti, Enzo Gallo, Theodora Daralioti, Letizia Perracchio, Andrea Sacconi, Patrizia Pasanisi, Paola Muti, Claudio Pulito, Sabrina Strano, Zaira Ianniello, Alessandro Fatica, Mattia Forcato, Francesco Fazi, Giovanni Blandino, Giulia Fontemaggi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-17 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03539-x
Popis: The circular isoform of VEGFA mRNA (circ_0076611), associated with size and pathogenesis of triple-negative breast tumors, is produced via back splicing of exon-7 by a RNP complex comprising lncRNA-MALAT1, ID4 and SRSF1, and secreted through exosomes.
Databáze: Directory of Open Access Journals
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