Clinical–EEG-Neuroimmunological Correlations in Depressive Female Adolescents with Non-Suicidal Self-Injuries
| Autor: | A. Iznak, E. Iznak, I. Oleichik, S. Zozulya |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | European Psychiatry, Vol 65, Pp S325-S325 (2022) |
| Druh dokumentu: | article |
| ISSN: | 0924-9338 1778-3585 |
| DOI: | 10.1192/j.eurpsy.2022.827 |
| Popis: | Introduction Non-suicidal self-injurious behavior (NSSI) is rather widespread in adolescents, especially in females, and is an important risk factor for future suicide. The search for neurobiological markers of NSSI is therefore an actual medical and social problem. Objectives The aim of the study was to determine the relationships between pre-treatment quantitative clinical, EEG, and neuroimmunological parameters in female depressive adolescents with NSSI. Methods 40 female depressive patients (all right-handed, 16–25 years old, mean 17.6±2.2 years old) were included in the study. Total HDRS-17 scores varied from 14 to 38 (mean 26.0±6.9). Multichannel eyes closed resting EEG was recorded with subsequent spectral power (SP) measurements in narrow frequency sub-bands. Enzymatic activities of leukocyte elastase (LE) and its antagonist α-1 proteinase inhibitor (α1-PI), as neuroinflammation markers, and the levels of autoantibodies to S100b protein (AAB-S100b) and to basic myelin protein (AAB-BMP), as neuroplasticity markers, were measured in the blood plasma. Spearman’s rank correlations were calculated between clinical, EEG, and neuroimmunological parameters. Results HDRS-17 scores correlated positively (p |
| Databáze: | Directory of Open Access Journals |
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