In vivo bone regeneration by differently designed titanium membrane with or without surface treatment: a study in rat calvarial defects

Autor: Yong-Seok Jang, So-Hee Moon, Thuy-Duong Thi Nguyen, Min-Ho Lee, Tae-Ju Oh, A-Lum Han, Tae-Sung Bae
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Journal of Tissue Engineering, Vol 10 (2019)
Druh dokumentu: article
ISSN: 2041-7314
20417314
DOI: 10.1177/2041731419831466
Popis: The current objective was to evaluate six groups of titanium membranes in a rat calvarial defect model, regarding the surface treatment with or without calcium-phosphate coating and surface topography with no, small, or large holes. Critical size defects (Ф = 8 mm, n = 42) were surgically created in rat calvaria, and then were treated by one of the six groups. Biopsies were obtained at 4 weeks (n = 5 per group) for micro-computed tomography and histomorphometric analyses. Fluorochrome bone markers were injected in two rats each group at 1 (Alizarin red), 3 (Calcein green) and 5 weeks (Oxytetracyclin yellow), followed by histological examination at 7 weeks to assess bone regeneration dynamic. At 4 weeks, the highest bone volume was observed in no-hole groups independent of surface treatment ( p
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