Cord blood superoxide dismutase and glutathione peroxidase activity in premature infants
| Autor: | Guržanova-Durnev Liljana, Zisovska Elizabeta, Đošić-Markovska Božidarka |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Journal of Medical Biochemistry, Vol 33, Iss 2, Pp 208-215 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1452-8258 1452-8266 |
| Popis: | Background: Birth involves strong oxidative stress for the infant, implying an increased production of free radicals. The aims of this study were to assess the antioxidant response to oxidative insult at birth, by estimating the superoxide dismutase (SOD) and glutathione peroxidase (GPX) activity in umbilical cord blood, and to evaluate their dependency on the degree of maturation of the newborns. Methods: In the present study, 60 preterm infants (study group) as well as a full-term healthy reference group (A=53) were included. Additionally, the preterms were divided in 3 groups according to their condition at the end of the 1st week of life: preterm control (B=25), on oxygen support (C=18), and ventilated group (D=17). Results: The obtained results indicate markedly lower antioxidant capacity of the preterm infants: they had significantly lower SOD and G PX activity than the full-term infants (p |
| Databáze: | Directory of Open Access Journals |
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