Evaluation of the relationship and postoperative glomerular filtration rate between the living donor and the recipients in kidney transplantation

Autor: Guang-Heng Chen, Hsi-Hsien Wang, Po-Jen Hsiao, Yi-Huei Chang, Shen-Wei Li, Chi-Ping Huang, Chin-Chung Yeh, Chao-Hsiang Chang
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: Urological Science, Vol 28, Iss 4, Pp 227-231 (2017)
Druh dokumentu: article
ISSN: 1879-5226
DOI: 10.1016/j.urols.2016.10.005
Popis: Objective: This study evaluated the relationship and postoperative glomerular filtration rate (GFR) between the living donors and the recipients in kidney transplantation. A 5-year review of living donor renal transplants in a single transplant center was performed. Materials and methods: From January 2010 to February 2015, a total of 49 living donor kidney transplantations were performed at the China Medical University Hospital, Taichung, Taiwan. The relationship between donor and recipient and graft survival and changes in GFR during a 5-year period in a single center were retrospectively analyzed. Results: These 49 living donor kidney transplants represent 68% of all transplants (49/72) that were performed during this 5-year review. The recipients' kidneys were donated from offspring donors (22.4%; mean age, 54.27 years), parent donors (32.7%; mean age, 27.56 years), sibling donors (24.5%; mean age, 37.18 years), and spouse donors (20.4%; mean age, 49.09 years). The GFRs of the recipients were significantly different between these four groups at the last follow-up. The mean last follow-up postoperative GFR of the recipients was 77.71 mL/min for offspring donors, 57.81 mL/min for parents donors, 61.17 mL/min for sibling donors, and 46.30 mL/min for the spouse donors (p=0.004). Two graft losses were noted in the spouse living donor population due to infection (cytomegalovirus and urinary tract infection). Conclusion: This study shows that the relationship of the donor to their recipient resulted in significant differences in the postoperative GFR and graft loss of the recipients. Recipients' kidneys donated from the spouse had the worst GFR compared to other groups.
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