Assessment of the mean dose of the pharyngeal constrictor muscles (as one organ) as a part of DARS and its effect on dysphagia in IMRT treated head and neck cancer patients

Autor: May Gamal Ashour, Tarek Hamed Shouman, Ashraf Hamed Hassouna, Maha Hassan Mokhtar, Dalia Abdelfatah
Jazyk: angličtina
Rok vydání: 2025
Předmět:
Zdroj: Oral Oncology Reports, Vol 13, Iss , Pp 100689- (2025)
Druh dokumentu: article
ISSN: 2772-9060
DOI: 10.1016/j.oor.2024.100689
Popis: Objective: To assess the mean dose the pharyngeal constrictor muscle (PCM) received and its effect on dysphagia and develop a cut-off value for its occurrence. Methods: 116 patients with head and neck cancer who required bilateral neck irradiation treated using the simultaneous integrated boost IMRT technique were retrospectively evaluated. Pharyngeal constrictor (superior, middle, inferior) and cricopharyngeus and esophageal inlet muscles (cricopharyngeal inlet) were considered dysphagia/aspiration-related structures (DARS) and were summated as one organ at risk structure PCM. PlanPCM consists of the sum of one or multiple pharyngeal constrictor muscles away from high-risk volumes. Results: This study enrolled 116 patients (37 female, 79 male), mean age of 51 years. The mean dose to PCM was 51.37 Gy ± SD (range, 30.08–63.86 Gy). The severity of dysphagia correlated significantly with the dose received by PlanPCM (p
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