Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction

Autor: Gautam Srivastava, Meng S. Choy, Nicolas Bolik-Coulon, Rebecca Page, Wolfgang Peti
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-023-37372-5
Popis: Protein phosphatase 1 (PP1) is regulated by intrinsically disordered proteins like inhibitor-3, I3. The authors show that I3 does not inhibit PP1 by forming a rigid complex but instead by binding dynamically with its active site metals, showing how flexibility is used in biology.
Databáze: Directory of Open Access Journals