An Efficient Synthesis of γ-Aminoacids and Attempts to Drive Its Enantioselectivity

Autor:	Pablo Rodríguez, Margarita Parra, Salvador Gil
Jazyk:	angličtina
Rok vydání:	2008
Předmět:	GABA γ-aminoacids bromoacetonitrile enediolate regioselectivity. Organic chemistry QD241-441
Zdroj:	Molecules, Vol 13, Iss 4, Pp 716-728 (2008)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules13040716
Popis:	Addition of carboxylic acid dianions to bromoacetonitrile lead, in good yields,to the corresponding γ-cyanoacids, which on hydrogenation yielded γ-aminoacids. Thistwo step methodology improves upon previously described results. Poor e.e’s resultedfrom our attempts to drive the enantioselectivity of this transformation by chiral amideinduction.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bc074997ed7848b3a9b08e0d4e46ec30 Zobrazit plný text záznamu View record in DOAJ