In vitro activity of 1,3-bisaryloxypropanamines against Trypanosoma cruzi-infected L929 cultures

Autor:	Stefânia Neiva Lavorato, Policarpo Ademar Sales Júnior, Silvane Maria Fonseca Murta, Alvaro José Romanha, Ricardo José Alves/
Jazyk:	angličtina
Rok vydání:	2015
Předmět:	Trypanosoma cruzi antitrypanosomal agents Chagas disease 1 3-bisaryloxypropanamines Microbiology QR1-502 Infectious and parasitic diseases RC109-216
Zdroj:	Memorias do Instituto Oswaldo Cruz, Vol 110, Iss 4, Pp 566-568 (2015)
Druh dokumentu:	article
ISSN:	1678-8060 0074-0276
DOI:	10.1590/0074-02760150007
Popis:	We describe herein the antitrypanosomal activity of 20 novel 1,3-bis(aryloxy)propan-2-amine derivatives. Compounds 2, 4, 6, 12, 15, 16 and 19 were significantly active against amastigote and trypomastigote forms, with half maximal inhibitory concentrationvalues in the range of 6-18 µM. In the cytotoxicity tests against L929 cells, only compound 4 presented selectivity index value above 10, indicating low toxicity.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/ebc073d2e53f40df93a1a0921428ba00 Zobrazit plný text záznamu View record in DOAJ