Assistance for Folding of Disease-Causing Plasma Membrane Proteins

Autor: Karina Juarez-Navarro, Victor M. Ayala-Garcia, Estela Ruiz-Baca, Ivan Meneses-Morales, Jose Luis Rios-Banuelos, Angelica Lopez-Rodriguez
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Biomolecules, Vol 10, Iss 5, p 728 (2020)
Druh dokumentu: article
ISSN: 10050728
2218-273X
DOI: 10.3390/biom10050728
Popis: An extensive catalog of plasma membrane (PM) protein mutations related to phenotypic diseases is associated with incorrect protein folding and/or localization. These impairments, in addition to dysfunction, frequently promote protein aggregation, which can be detrimental to cells. Here, we review PM protein processing, from protein synthesis in the endoplasmic reticulum to delivery to the PM, stressing the main repercussions of processing failures and their physiological consequences in pathologies, and we summarize the recent proposed therapeutic strategies to rescue misassembled proteins through different types of chaperones and/or small molecule drugs that safeguard protein quality control and regulate proteostasis.
Databáze: Directory of Open Access Journals
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