Anti-Inflammatory And Anti-Oxidant Activities Of Glochidion Daltonii Branch Extract
| Autor: | Jintana Junlatat, Bungorn Sripanidkulchai |
|---|---|
| Jazyk: | indonéština |
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Jurnal Farmasi dan Ilmu Kefarmasian Indonesia, Vol 3, Iss 2, Pp 39-43 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2406-9388 2580-8303 |
| DOI: | 10.20473/jfiki.v3i22016.39-43 |
| Popis: | Background: Glochidion daltonii (MÜll. Arg.) Kurz, Euphorbiaceae family, is a native medicinal plant in tropical regions of Asia. In Thailand, it has traditionally been used for treating pain and mouth inflammation. Objective: This study aims to investigate the anti-inflammatory and anti-oxidant effects of G. daltonii ethanolic extract (GDE) both in vitro and in vivo. Method: The anti-inflammatory mechanism was examined in E.coli LPS-stimulated RAW264.7 cells by using semi-quantitative-reverse transcription-polymerase chain reaction and the potential anti-inflammatory effect of GDE was evaluated in Sprague-Dawley rat using carrageenan-induced rat paw edema method. In addition, DPPH assay was used for anti-oxidant evaluation. Result: The results showed that GDE at 0.063 - 0.250 mg/mL concentrations inhibited the expressions of tumor necrosis factor-α and interleukin-1β. Moreover, an intraperitoneal administration of GDE significantly reduced paw edema in rats. Furthermore, GDE showed high anti-oxidant property with IC50 values at 6.35 ± 0.28 µg/mL. Conclusion: The results support the traditionally use of GDE for treating inflammation. |
| Databáze: | Directory of Open Access Journals |
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