| Autor: |
Lucy J. Newbury, Kate Simpson, Usman Khalid, Imogen John, Lluís Bailach de Rivera, Yueh-An Lu, Melisa Lopez-Anton, William J. Watkins, Robert H. Jenkins, Donald J. Fraser, Timothy Bowen |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-021-94984-x |
| Popis: |
Abstract Acute kidney injury (AKI) is a global clinical problem characterised by a sudden decline in renal function and mortality as high as 60%. Current AKI biomarkers have limited ability to classify disease progression and identify underlying pathological mechanisms. Here we hypothesised that alterations in urinary microRNA profiles could predict AKI recovery/nonrecovery after 90 days, and that injury-specific changes would signify microRNA mediators of AKI pathology. Comparison of urinary microRNA profiles from AKI patients with controls detected significant injury-specific increases in miR-21, miR-126 and miR-141 (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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