Bioactive Pregnane Steroids from a South China Sea Gorgonian Carijoa sp.
| Autor: | Fei Cao, Chang-Yun Wang, Lei Han, Zhi-Yong Li, Chang-Lun Shao, Hong-Ying Zhao |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: | |
| Zdroj: | Molecules, Vol 18, Iss 3, Pp 3458-3466 (2013) |
| Druh dokumentu: | article |
| ISSN: | 18033458 1420-3049 |
| DOI: | 10.3390/molecules18033458 |
| Popis: | A new pregnane steroid, 1, and three known analogues 2–4, have been isolated from a gorgonian Carijoa sp. collected from the South China Sea. The planar structure and relative configuration of 1 were elucidated from comprehensive spectroscopic data. Its absolute configuration was determined by application of the modified Mosher method. Compounds 1, 3 and 4 exhibited cytotoxicity against the human hepatoma cell line Bel-7402, with IC50 values of 9.33, 11.02 and 18.68 µM, respectively. Additionally, compound 1 exhibited promising antibacterial activity against Pseudomona puido, with a MIC value of 31 nM, which is approximately 5-fold more potent than ciprofloxacin (MIC = 156 nM). |
| Databáze: | Directory of Open Access Journals |
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