Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi

Autor:	Angeliki Sofia Foscolos, Andrew Tsotinis, Martin C. Taylor, John M. Kelly, Ioannis P. Papanastasiou
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	4-(adamant-1-yl)phenyl 4-(adamant-1-yl)phenoxy arylhydroxamides anti-trypanosomal activity Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2022, Iss 2, p M1363 (2022)
Druh dokumentu:	article
ISSN:	1422-8599
DOI:	10.3390/M1363
Popis:	In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c. The 4-(adamant-1-yl)phenyl- and 4-(adamant-1-yl)phenoxy- moieties, which are endowed with promising drug-like properties, are functionalized at the side chain termini as hydroxamic acids. The phenoxy acetohydroxamic derivative, 1c, shows the most interesting profile in terms of activity and toxicity against trypanosomes and merits further investigation.
Databáze:	Directory of Open Access Journals
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