| Autor: |
Seobin Yoon, Eui-Hwan Choi, Jung-Woong Kim, Keun P. Kim |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
Experimental and Molecular Medicine, Vol 50, Iss 8, Pp 1-12 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2092-6413 |
| DOI: |
10.1038/s12276-018-0139-5 |
| Popis: |
Cell division: Recombination in action Using very high resolution microscopy, Korean researchers are able to visualize meiosis, a two-step division process that ensures that each egg or sperm cell has a single set of chromosomes, in unprecedented detail. After DNA replication and before the first division cycle, pairs of chromosomes align to exchange genetic material, a process known as recombination. This process is facilitated by multi-protein structures called synaptonemal complexes (SCs) that hold the chromosomes together. Keun Kim and colleagues at Chung-Ang University, Seoul, South Korea used structured illumination microscopy to observe SCs during meiosis in mouse sperm-forming cells. They found that the position of replication protein A, a key regulator of recombination, on the SC changes as recombination takes place. These findings suggest that RPA location on SCs could be used to monitor the progression of meiotic recombination. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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