| Autor: |
Oluwatosin Kudirat Shittu, Olawale Issac Oluyomi, Theresa Yebo Gara |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Clinical Phytoscience, Vol 7, Iss 1, Pp 1-8 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2199-1197 |
| DOI: |
10.1186/s40816-021-00314-z |
| Popis: |
Abstract Background In the wake of antibiotic resistance, treatment of intractable wound have been very challenging and any alternative treatment which may lead to less use of antibiotics deserves further exploitation. Nanoparticle conjugates has potentially not only reduce antibiotic use but it has been considered safe and effectively disinfect wounds already colonized with resistant bacteria as well as promoting granulation tissue formation. In this study, Iodine-doped silver nanoparticle Ointment (Ag-I NPs) was investigated for its toxicological effect on excisional wound of albino rats. Methods Aqueous extraction of Piper guineense leaf was carried out and used for the synthesis of Ag-I NPs. The synthesized Ag-I NPs were characterized by Ultraviolet visible spectrophotometer which confirmed the availability of silver nanoparticles. The particles were then used to prepare a wound healing ointment for treating excision wound inflicted on wistar rat model. Blood samples, liver and kidney biopsies were collected on the 21st day of the experiment from all the rats for hematology, biochemical and histopathological analysis. Result In the hematological and biochemical analysis, hemoglobin (Hb), packed cell volume (PCV) and mean corpuscular hemoglobin (MCH), superoxide dismutase (SOD), alkaline phosphatase (ALP) of experimental rats treated with Ag-I NPs were significantly different (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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