| Autor: |
Mariana Serpa, Sabri S. Sanabani, Israel Bendit, Fernanda Seguro, Flávia Xavier, Cláudia Bitti Barroso, Monika Conchon, Pedro Enrique Dorlhiac-Llacer |
| Jazyk: |
angličtina |
| Rok vydání: |
2010 |
| Předmět: |
|
| Zdroj: |
Clinical Medicine Insights: Oncology, Vol 4 (2010) |
| Druh dokumentu: |
article |
| ISSN: |
1179-5549 |
| DOI: |
10.4137/CMO.S6413 |
| Popis: |
We report our experience in 4 patients with chronic myeloid leukemia (CML) who had discontinued imatinib as a result of adverse events and had switched to dasatinib. The chronic phase ( n 2) and accelerated phase ( n 2) CML patients received dasatinib at starting dose of 100 and 140 mg once daily, respectively. Reappearance of hematological toxicity was observed in 3 patients and pancreatitis in one patient. Treatment was given at a lower dose and patients were followed. The median follow-up was 13 months and the median dose of dasatinib until achievement of complete cytogenetic remission (CCyR) was 60 mg daily (range = 20 to 120 mg). All four patients had achieved CCyR at a median of 4 months (range = 3 to 5 months) and among them, three had also achieved major molecular remission. We conclude that low-dose dasatinib therapy in intolerant patients appears safe and efficacious and may be tried before drug discontinuation. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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