The epidemiological impact and cost-effectiveness of key population-led PrEP delivery to prevent HIV among men who have sex with men in Thailand: A modelling studyResearch in context

Autor: Lisbeth Versteegh, Sorawit Amatavete, Tanat Chinbunchorn, Noppawith Thammasiha, Shreoshee Mukherjee, Stephanie Popping, Ratthaphon Triamvichanon, Artit Pusamang, Donn J. Colby, Matthew Avery, Stephen Mills, Nittaya Phanuphak, Reshmie A. Ramautarsing, David van de Vijver
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: The Lancet Regional Health - Southeast Asia, Vol 7, Iss , Pp 100097- (2022)
Druh dokumentu: article
ISSN: 2772-3682
DOI: 10.1016/j.lansea.2022.100097
Popis: Summary: Background: Although key populations (KPs), such as men-who-have-sex-with-men (MSM) are disproportionately affected by HIV, many prevention and treatment services are not easily accessible for KP members. To address the needs of KPs, Thailand established pre-exposure prophylaxis (PrEP) service delivery together with and led by KP members. This study determines the epidemiological impact and cost-effectiveness of key population-led (KP-led) PrEP. Methods: We calibrated a compartmental deterministic HIV transmission model to the HIV epidemic among Thai MSM. Besides KP-led PrEP, we included other Thai service delivery models of PrEP (fee-based PrEP, the government PrEP program).Data on consistent PrEP use (5 years daily use, 95% effectiveness for preventing HIV) came from Thai PrEP delivery models. For the period 2015–2032, we ranged the number of PrEP starters (40,000–120,000), effectiveness of PrEP (45%–95%), and proportion of consistent users (10%–50%). The analysis started in 2015 when PrEP was introduced. A cost-effectiveness ratio of
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