| Autor: |
CH.B. Praveena Devi, K. Vijay, B. Hari Babu, Syed Farooq Adil, M. Mujahid Alam, M. Vijjulatha, Mohd. Bismillah Ansari |
| Jazyk: |
angličtina |
| Rok vydání: |
2019 |
| Předmět: |
|
| Zdroj: |
Journal of Saudi Chemical Society, Vol 23, Iss 7, Pp 980-991 (2019) |
| Druh dokumentu: |
article |
| ISSN: |
1319-6103 |
| DOI: |
10.1016/j.jscs.2019.05.002 |
| Popis: |
A novel series of conjugates of benzosuberone and 1,2,3-triazole i.e. 3-(4-phenyl-1H-1,2,3-triazol-1-yl)propyl-9-chloro-2,3-dimethyl-6,7-dihydro-5H-benzo[7]annulene-8-carboxylic acids (8a-j) were synthesized in good to excellent yields catalysed by CuSO4 under milder reaction conditions and evaluated for their anti-proliferative activity. The structural elucidation of the prepared compounds was carried out using IR, 1H NMR, 13C NMR and Mass spectral analysis. The newly synthesized derivatives (8a-j) were evaluated for their anti-proliferative activity against four human cell lines and the novel derivatives showed moderate to excellent activity. The obtained results suggest that these compounds can be considered as new hits for anti-proliferative drug development programme and further SAR studies can help obtain better anticancer agents. Keywords: Benzosuberone, Triazole derivative, Anti-proliferative activity, Molecular docking |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
