Accurate quantification of pulmonary perfusion ratio in children with congenital heart disease using partial volume corrected 4D flow cardiac magnetic resonance

Autor: Kerstin Lagerstrand, Anna Nyström, Pär-Arne Svensson, Charlotte De Lange, Frida Dangardt
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Pediatrics, Vol 12 (2024)
Druh dokumentu: article
ISSN: 2296-2360
DOI: 10.3389/fped.2024.1339679
Popis: BackgroundIn children with congenital heart disease (CHD), lung scintigraphy is the reference standard for evaluation of pulmonary perfusion. 4D flow CMR offers a non-ionizing alternative. Due to the intrinsic limitation in the spatial resolution, however, 4D flow may display clinically unacceptable differences compared to the reference standard. This case study aims to highlight the importance of correcting for such partial volume errors to accurately evaluate pulmonary perfusion in small pulmonary arteries.MethodsChildren with CHD, mainly those with transposition of the great arteries or tetralogy-of-Fallot, referred to CMR from 2020 to 2022 at our clinic, were retrospectively reviewed; n = 37. All patients had been examined with a free breathing, motion-corrected 4D flow protocol. Comparison in pulmonary perfusion (PPR: relative flow through right and left pulmonary arteries) with scintigraphy were performed both for 4D flow before and after partial volume correction.ResultsPatients with large pulmonary arteries, 76%, displayed small differences in PPR between modalities (
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