Original enzyme-catalyzed synthesis of chalcones: Utilization of hydrolase promiscuity
| Autor: | Mitrev Yavor N., Mehandzhiyski Aleksander Y., Batovska Daniela I., Liese Andreas, Galunsky Boris |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Journal of the Serbian Chemical Society, Vol 81, Iss 11, Pp 1231-1237 (2016) |
| Druh dokumentu: | article |
| ISSN: | 0352-5139 1820-7421 |
| DOI: | 10.2298/JSC160422069M |
| Popis: | E-chalcone was obtained with very high stereoselectivity for the first time by an enzyme-catalyzed Claisen-Schmidt condensation between benzaldehyde and acetophenone. From a set of lipases, only that from hog pancreas demonstrated promiscuity, catalyzing the reaction in the presence of imidazole as a promoter. Another enzyme, acylase from Aspergillus melleus (3.5.1.14) also proved to be active in the synthesis of E-chalcone under the same reaction conditions. This acylase along with the recombinant D-aminoacylase (3.5.1.81) catalyzed also the reaction between acetophenone and p-nitrobenzaldehyde. Such “green” approach to synthesis of chalcones is of great interest, because of their important applications as formula ingredients in pharmaceutical, food and cosmetic industry. |
| Databáze: | Directory of Open Access Journals |
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