New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas
| Autor: | Marie Donzel, Lucile Baseggio, Juliette Fontaine, Florian Pesce, Hervé Ghesquières, Emmanuel Bachy, Aurélie Verney, Alexandra Traverse-Glehen |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Current Oncology, Vol 28, Iss 5, Pp 3430-3447 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1718-7729 1198-0052 |
| DOI: | 10.3390/curroncol28050297 |
| Popis: | Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-chemotherapy or splenectomy, with all associated side effects. In recent years, advances in the comprehension of SMZL physiopathology have multiplied, thanks to the arrival of new devices in the panel of available molecular biology techniques, allowing the discovery of new molecular findings. In the era of targeted therapies, an update of current knowledge is needed to guide future researches, such as those on epigenetic modifications or the microenvironment of these lymphomas. |
| Databáze: | Directory of Open Access Journals |
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