Prevalence and Associated Factors of Cryptococcal Antigenemia in HIV-Infected Patients with CD4 < 200 Cells/µL in São Paulo, Brazil: A Bayesian Analysis

Autor: Evanthia Vetos Mimicos, Victor Fossaluza, Camila de Melo Picone, Camila Caroline de Sena, Hélio Rodrigues Gomes, Carolina dos Santos Lázari, Fernanda Ferreira da Silva, Erika Shimoda Nakanishi, Isabelle Vichr Nisida, Angela Carvalho Freitas, Ronaldo Borges Gryschek, Eduardo Ronner Lagonegro, Márcia Lazéra, Maria Aparecida Shikanai-Yasuda
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Journal of Fungi, Vol 8, Iss 12, p 1284 (2022)
Druh dokumentu: article
ISSN: 2309-608X
DOI: 10.3390/jof8121284
Popis: Cryptococcosis is a severe life-threatening disease and a major cause of mortality in people with advanced AIDS and CD4 ≤ 100 cells/µL. Considering the knowledge gap regarding the benefits of routine application of antigenemia tests in HIV-infected patients with 100–200 CD4 cells/µL for the prevention of cryptococcal meningitis (CM), we aimed to evaluate the prevalence of positive antigenemia through lateral flow assay (LFA) and associated factors in HIV-infected patients with CD4 < 200 cells/µL. Our findings of 3.49% of positive LFA (LFA+) patients with CD4 < 100 cells/µL and 2.24% with CD4 between 100–200 cells/µL have been included in a Bayesian analysis with 12 other studies containing similar samples worldwide. This analysis showed a proportion of 3.6% LFA+ patients (95% credible interval-Ci [2.5–5.7%]) with CD4 < 100 cells/µL and 1.1% (95%Ci [0.5–4.3%]) with CD4 between 100–200 cells/µL, without statistical difference between these groups. The difference between mortality rates in LFA+ and negative LFA groups was e = 0.05013. Cryptococcoma and CM were observed in the LFA+ group with 100–200 and
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