| Autor: |
Karla Veruska Marques Cavalcante, Nádja de Azevedo Correia, Katy Lísias Gondim Dias, Darizy Flávia Silva, José Couras Silva-Filho, Islania Giselia Albuquerque Araújo, Bruno Farias Lira, Petrônio Athayde-Filho, Isac Almeida Medeiros |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
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| Zdroj: |
Journal of Pharmacological Sciences, Vol 110, Iss 1, Pp 29-35 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.FP0071581 |
| Popis: |
Abstract.: This study was performed to investigate the mechanisms involved in the vasorelaxation induced by mesoionic 2-(4-chlorophenyl)-3-methyl-4-(4-methoxyphenyl)-1;3-thiazolium-5-thyolate (CMMTT), a newly synthesized mesoionic compound, in rat superior mesenteric arteries. In phenylephrine (10 μM)–pre-contracted mesenteric rings, CMMTT (10−14 –10− 6 M) induced a concentration-dependent relaxation [pD2 = 10.26 ± 0.05, Emax = 80.8 ± 5.8%], and this effect was almost abolished after either removal of the vascular endothelium [Emax = 17.7 ± 4.2%, P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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