Humoral Acute Rejection in a Kidney Transplant Recipient with Idiopathic Thrombocytopenic Purpura
| Autor: | Ana Paola Rico-Portillo, José Ignacio Cerrillos-Gutierrez, Jorge Andrade-Sierra, Alfredo Gutiérrez-Govea, Enrique Rojas-Campos, Claudia Alejandra Mendoza-Cerpa, Benjamín Gómez-Navarro |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Case Reports in Transplantation, Vol 2021 (2021) |
| Druh dokumentu: | article |
| ISSN: | 2090-6943 2090-6951 |
| DOI: | 10.1155/2021/9933354 |
| Popis: | A 47-year-old male was diagnosed with chronic kidney disease (CKD) in 2011; idiopathic thrombocytopenic purpura (ITP) was also diagnosed in 2011 refractory to medical treatment and finally treated with splenectomy (2017) without relapses since that date, 5 blood transfusions, and 4 platelet apheresis in 2017. Renal transplant from a living related donor (brother), ABO compatible, crossmatch were negative, sharing 1 haplotype. Donor-specific anti-HLA antibody was negative. Graft function was stable until the 5th day and graft biopsy on the 6th day; thrombotic microangiopathy (TMA), C4D negative and inflammatory infiltration of polymorphonuclear leukocytes inside peritubular capillary, and anti-MICA antibodies were positive. The treatment used were plasmapheresis, intravenous immunoglobulin, and rituximab. Serum creatinine began to decrease since the 14th day, and by day 33, post-RT graft function was restored. |
| Databáze: | Directory of Open Access Journals |
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