Genetic variants in BDNF (rs6265 and rs11030119) and stroke susceptibility: a case-control analysis in South India
| Autor: | Anushree Muraleedharan Nair, Chandrasudan Ramamoorthi, Madhushri Arumugam Senthilkumar, Remasri Kanniyapillai, Praveen Kumar Chandra Sekar, Akram Husain Rehman Syed Rasheed, Subramaniyan Kannaian, Ramakrishnan Veerabathiran |
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| Jazyk: | angličtina |
| Rok vydání: | 2024 |
| Předmět: | |
| Zdroj: | Annals of Human Biology, Vol 51, Iss 1 (2024) |
| Druh dokumentu: | article |
| ISSN: | 03014460 1464-5033 0301-4460 |
| DOI: | 10.1080/03014460.2024.2415984 |
| Popis: | Background Stroke occurs when the blood supply to part of the cerebral cortex is blocked, depriving it of oxygen and glucose, leading to cell death. It is a multifactorial disorder influenced by genetic, vascular, and environmental factors.Aim This study investigated the association between two polymorphisms of the brain-derived neurotrophic factor (BDNF) gene, rs6265 and rs11030119, and stroke risk in a South Indian population.Subjects and Methods The study included 163 stroke cases and 160 healthy controls. Genomic DNA was extracted, and genotyping of rs6265 and rs11030119 polymorphisms was done using ARMS-PCR. Allelic and genotype frequencies were calculated, and odds ratios (OR) with 95% confidence intervals (CI) were determined using SPSS version 21.0.Results The rs6265 polymorphism was significantly associated with stroke risk, with the GG genotype more frequent in controls (OR 1.79, 95% CI 1.05–1.76, p = 0.01). The rs11030119 polymorphism showed a positive association, with the AA genotype more prevalent in cases (OR 2.70, 95% CI 1.34–5.44, p = 0.003).Conclusion This study suggests an association between BDNF polymorphisms (rs6265, rs11030119) and stroke risk in a South Indian population. Further research in larger populations is necessary to confirm these findings and explore the mechanisms involved. |
| Databáze: | Directory of Open Access Journals |
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