Altered levels of immune-regulatory microRNAs in plasma samples of patients with lupus nephritis

Autor: Sepideh Zununi Vahed, Mohammadreza Nakhjavani, Jalal Etemadi, Henghame Jamshidi, Nima Jadidian, Tala Pourlak, Sima Abediazar
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BioImpacts, Vol 8, Iss 3, Pp 177-183 (2018)
Druh dokumentu: article
ISSN: 2228-5660
2228-5652
DOI: 10.15171/bi.2018.20
Popis: Introduction: Lupus nephritis (LN) is a major cause of mortality and morbidity in the patients with lupus, a chronic autoimmune disease. The role of genetic and epigenetic factors is emphasized in the pathogenesis of LN. The aim of the present study was to evaluate the levels of immune-regulatory microRNAs (e.g., miR-31, miR-125a, miR-142-3p, miR-146a, and miR-155) in plasma samples of patients with LN. Methods: In this study, 26 patients with LN and 26 healthy individuals were included. The plasma levels of the microRNAs were evaluated by a quantitative real-time PCR. Moreover, the correlation of circulating plasma microRNAs with disease activity and pathological findings along with their ability to distinguish patients with LN were assessed. Results: Plasma levels of miR-125a (P = 0.048), miR-146a (P = 0.005), and miR-155 (P< 0.001) were significantly higher in comparison between the cases and controls. The plasma level of miR-146a significantly correlated with the level of anti-double strand-DNA antibody and proteinuria. Moreover, there was a significant correlation between miR-142-3p levels and disease chronicity and activity index (P
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