Insights into solid dosage forms with nonlinear optical imaging
| Autor: | Teemu Tomberg, Alba Maria Arbiol Enguita, Clare Strachan |
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| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Journal of Medical Science, Vol 92, Iss 3 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2353-9798 2353-9801 |
| DOI: | 10.20883/medical.e914 |
| Popis: | Microscopic chemical and solid-state structures and their changes in solid drugs and dosage forms can profoundly affect pharmaceutical performance and patient safety. Despite this, their detailed spatially-resolved analysis can be difficult or impossible with established analytical technologies. Multimodal non-linear optical imaging represents opportunities for sensitive and specific chemical and solid-state pharmaceutical imaging. Non-linear optical imaging encompasses several nonlinear optical phenomena, including coherent anti-Stokes Raman scattering (CARS), stimulated Raman scattering (SRS), and sum frequency/second harmonic generation (SFG/SHG). Imaging in 3D with (sub)micron resolution is rapid, non-destructive, possible in situ in aqueous media, and generally does not require prior sample preparation. This mini-review explores several applications of non-linear optical imaging for solid drug and dosage form analysis. |
| Databáze: | Directory of Open Access Journals |
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