Age‐ and disease‐specific reference values for neurofilament light presented in an online interactive support interface

Autor:	Lisa Vermunt, Marco Otte, Inge M. W. Verberk, Joep Killestein, Afina W. Lemstra, Wiesje M. van derFlier, Yolande A. L. Pijnenburg, Everard G. B. Vijverberg, Femke H. Bouwman, Gido Gravesteijn, Wilma D. J. van deBerg, Philip Scheltens, Argonde C. vanHarten, Eline A. J. Willemse, Charlotte E. Teunissen
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Zdroj:	Annals of Clinical and Translational Neurology, Vol 9, Iss 11, Pp 1832-1837 (2022)
Druh dokumentu:	article
ISSN:	2328-9503
DOI:	10.1002/acn3.51676
Popis:	Abstract Interpretation of axonal damage biomarker Neurofilament Light chain (NfL) concentrations is difficult due to the lack of age‐specific and disease‐specific reference values. We here developed an interactive interface to support interpretation of NfL results in human body fluids. We used NfL values of 1698 individuals without a neurological disorder, aged 19–85 years, and patients with MS and dementias. Percentile regression estimates per diagnosis populate interactive graphs, alongside NfL background information (available on: https://mybiomarkers.shinyapps.io/Neurofilament). This accessible interface provides reference for interpretation of the individual patient results for clinicians. It showcases an adaptable method to support interpretation of age‐dependent biomarkers in neurology.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/bb2c5e3e1a0f400bab820db7e4aec1eb Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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