Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress

Autor: Nancy N. Fang, Mang Zhu, Amalia Rose, Kuen-Phon Wu, Thibault Mayor
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Zdroj: Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/ncomms12907
Popis: Ubiquitination of misfolded proteins usually results in protein degradation. Here, the authors show that two deubiquitinases—enzymes that remove ubiquitin—are required for the proteasomal degradation of misfolded proteins in response to heat-shock in yeast.
Databáze: Directory of Open Access Journals