Association of lipoprotein(a) with platelet aggregation and thrombogenicity in patients undergoing percutaneous coronary intervention

Autor:	Pei Zhu, Xiao-Fang Tang, Ying Song, Yin Zhang, Li-Jian Gao, Zhan Gao, Jue Chen, Yue-Jin Yang, Run-Lin Gao, Bo Xu, Jin-Qing Yuan
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	lipoprotein(a) major adverse cardiovascular and cerebrovascular events percutaneous coronary intervention platelet aggregation thrombelastography Diseases of the blood and blood-forming organs RC633-647.5
Zdroj:	Platelets, Vol 32, Iss 5, Pp 684-689 (2021)
Druh dokumentu:	article
ISSN:	0953-7104 1369-1635 09537104
DOI:	10.1080/09537104.2020.1802412
Popis:	This study aimed to evaluate the association of lipoprotein(a) levels with platelet aggregation and thrombogenicity in patients undergoing percutaneous coronary intervention (PCI), and to investigate the ischemic outcome on this population. Lipoprotein(a) and modified thrombelastography were measured in 6601 consecutive patients underwent PCI on dual antiplatelet therapy. Cox proportional regression analysis was applied to illustrate the ischemic events in a 2-year follow up. The mean levels of lipoprotein(a) were 29.0 mg/dl. Patients with higher lipoprotein(a) levels had significantly accelerated fibrin generation (lower K time and bigger α angle) and greater clot strength (higher maximum amplitude (MA)) than patients with lower lipoprotein(a) levels (P
Databáze:	Directory of Open Access Journals
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