IMMUNITY IN PATIENTS WITH TROPHOBLASTIC DISEASE
| Autor: | B. O. Toloknov, E. G. Slavina, Z. G. Kadagidze, K. P. Laktionov, Е. Е. Makhova, A. I. Chertkova, I. V. Markina |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Опухоли женской репродуктивной системы, Vol 0, Iss 1-2, Pp 63-67 (2014) |
| Druh dokumentu: | article |
| ISSN: | 1994-4098 1999-8627 |
| DOI: | 10.17650/1994-4098-2009-0-1-2-63-67 |
| Popis: | The investigation included 39 female patients with different forms of trophoblastic disease whose immunity was studied by the cur- rently available procedures. The patients were divided into 2 groups. Group 1 comprised 29 patients with a history of hydatidiform mole, who received no chemotherapy (CT) since an analysis of the data did not show the presence of a trophoblastic tumor. Group 2 consisted of 10 patients with a verified trophoblastic tumor who received CT with various drugs. The patients with trophoblastic disease were found to have some abnormal immunological parameters; however, they differ little in patients with the malignant and benign course of the disease and cannot serve as a prognostic factor. Activated lymphocytes were substantially increased in both groups, suggesting an active immune response to antigen-foreign cells expressing along with parenteral antigens. The patients with hydatidiform mole have the sign to be further studied, that is a reduction in the count of СD25-positive Т lymphocytes, pos- sibly, suppressor cells. |
| Databáze: | Directory of Open Access Journals |
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