Case report: Personalized triple phage-antibiotic combination therapy to rescue necrotizing fasciitis caused by Panton-Valentine leukocidin-producing MRSA in a 12-year-old boy

Autor: Brieuc Van Nieuwenhuyse, Mathilde Balcaen, Olga Chatzis, Astrid Haenecour, Emilien Derycke, Thierry Detaille, Stéphan Clément de Cléty, Cécile Boulanger, Leïla Belkhir, Jean-Cyr Yombi, Julien De Greef, Olivier Cornu, Pierre-Louis Docquier, Audrey Lentini, Renaud Menten, Hector Rodriguez-Villalobos, Alexia Verroken, Sarah Djebara, Maya Merabishvili, Johann Griselain, Jean-Paul Pirnay, Laurent Houtekie, Dimitri Van der Linden
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
Druh dokumentu: article
ISSN: 2235-2988
DOI: 10.3389/fcimb.2024.1354681
Popis: Maximal standard-of-care (SOC) management could not stop the life-threatening progression of a necrotizing fasciitis induced by Panton-Valentine Leukocidin-producing Methicillin-Resistant Staphylococcus aureus (MRSA) in a 12-year-old boy. Multi-route phage therapy was initiated along with antibiotics against Staphylococcus aureus, Pseudomonas aeruginosa and Stenotrophomonas maltophilia, eventually leading to full recovery with no reported adverse events.
Databáze: Directory of Open Access Journals