Synthetic studies of Alkoxy isoindole-1,3-diones tetra-azabenzo[f]azulenes and their Antibacterial activity
| Autor: | M. Ahmed, R. Sharma, D. P. Nagda, V. K. Salvi, G. L. Talesara |
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| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: | |
| Zdroj: | E-Journal of Chemistry, Vol 3, Iss 1, Pp 28-34 (2006) |
| Druh dokumentu: | article |
| ISSN: | 0973-4945 2090-9810 |
| DOI: | 10.1155/2006/679374 |
| Popis: | 3-Methylpyrazol-5-one 3 reacts with substituted benzaldehydes 4a-d in the presence of anhydrous sodium acetate to produce the corresponding 4-arylidene-5-methyl-2,4-dihydro-pyrazol-3-ones 5a-d and the condensation of 5a-d with 2-bromoalkoxy-1H-isoindole-1, 3-(2H)-diones 2a-c furnished corresponding 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1,3-diones 6a-l, which on cyclisation with o-phenylendiamine give titled compounds 7a-l. All the synthesized compounds have been characterized by elemental analysis and spectral data and screened for their antibacterial properties against various bacterial strains in order to obtain chemotherapeutic properties. |
| Databáze: | Directory of Open Access Journals |
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