| Autor: |
CUI Ya-ting, GOU Wen-feng, WEI Hui-qiang, YU Jiang, HOU Wen-bin, LI Yi-liang |
| Jazyk: |
čínština |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Jichu yixue yu linchuang, Vol 41, Iss 5, Pp 753-757 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1001-6325 |
| Popis: |
Acidic nucleoplasmic DNA-binding protein 1 (And-1/WDHD1) as a natural chimerical protein, is characterized by containing the WD-repeat and the HMG-box motif families. And-1 is over-expressed in multiple tumors and involved in the whole cell cycle containing prereplication complex (Pre-RC) assembly, DNA replication, checkpoint activation, DNA repair and sister chromatid cohesion establishment. As a novel target for cell cycle regulation, And-1 can be used in the development of broad-spectrum anti-cancer drugs. This article focuses on the research on the structural characteristics, biochemical functions and potential roles of And-1 in cancer in recent years, in order to provide references for the further research of And-1 and the development of new drugs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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